trans-4-Amidinocyclohexanecarboxylic Acid 4-tert-Butylphenyl Ester, a Trypsin Inhibitor, Blocks Entry of HeLa Cells from G2 Phase into Mitosis.
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Human Serum Albumin Binding of 2-[(Carboxymethyl)sulfanyl]- 4-oxo-4-(4-tert-butylphenyl)butanoic Acid and its Mono-Me Ester
Interactions of 2-[(carboxymethyl)sulfanyl]-4-oxo-4-(4-tert-butylphenyl)butanoic acid (compound 1) and its mono-Me ester (compound 2) with the human serum albumin (HSA) have been studied by fluorescence spectroscopy. Comp. 1 exerts antiproliferative activity toward human tumor cells and significant selectivity (tumor vs. healthy cells) in vitro. Competitive binding study with warfarin and ibupr...
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The title compound, C(15)H(20)O(5)S, is an inter-mediate in the synthesis of a new type of poly(amido-amine) (PAMAM) dendrimer. The cyclo-hexane ring exhibits a chair conformation, with C-C bond lengths in the range 1.518 (3)-1.531 (3) Å and C-C-C angles in the range 110.45 (19)-112.09 (19)°; these agree well with the values in other cyclo-hexane derivatives described in the literature. In the ...
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The chirality of the title compound, C(19)H(26)O(2), is solely generated by the presence of the double bond in the cyclo-hexene ring. This compound was synthesized to study the inter-action of the two enanti-omers in the solid state. The resultant racemate is made up of carboxylic acid RS dimers. Inter-molecular O-H⋯O hydrogen bonds produce centrosymmetric R(2) (2)(8) rings which dimerize the t...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1993
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.16.829